InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAPK2

Summary

InnateDB Protein

IDBP-591390.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAPK2

Protein Name

death-associated protein kinase 2

Synonyms

DRP-1; DRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000453235

InnateDB Gene

IDBG-16095 (DAPK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0010506	regulation of autophagy
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0043276	anoikis
GO:0046777	protein autophosphorylation
GO:2001242	regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0031410	cytoplasmic vesicle
GO:0034423	autophagic vacuole lumen

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR018934 RIO-like kinase
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF01163

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt