InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TESPA1

Summary

InnateDB Protein

IDBP-591429.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TESPA1

Protein Name

KIAA0748

Synonyms

KIAA0748;

Species

Homo sapiens

Ensembl Protein

ENSP00000435622

InnateDB Gene

IDBG-38320 (TESPA1)

Protein Structure

UniProt Annotation

Function

Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269PubMed:22561606}.

Subcellular Localization

Cytoplasm. Endoplasmic reticulum membrane. Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM).

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding

Biological Process

GO:0010387	COP9 signalosome assembly
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0050862	positive regulation of T cell receptor signaling pathway