InnateDB Protein
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IDBP-591490.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANAPC15
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Protein Name
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chromosome 11 open reading frame 51
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Synonyms
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APC15; C11orf51;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000440002
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InnateDB Gene
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IDBG-63206 (ANAPC15)
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Protein Structure
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Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20. {ECO:0000269PubMed:21926987}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007067
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mitotic nuclear division
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GO:0090266
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regulation of mitotic cell cycle spindle assembly checkpoint
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P60006
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PhosphoSite |
PhosphoSite-
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TrEMBL |
F5H2T3
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UniProt Splice Variant |
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Entrez Gene |
25906
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UniGene |
Hs.38044
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RefSeq |
NP_001265416
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HUGO |
HGNC:24531
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OMIM |
614717
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CCDS |
CCDS8210
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HPRD |
13172
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IMGT |
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EMBL |
AF077206
AK222622
AL080071
AP000812
BC005156
BC005393
CH471076
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GenPept |
AAD27001
AAH05156
AAH05393
CAB45698
EAW74838
EAW74841
EAW74842
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