InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRK

Summary

InnateDB Protein

IDBP-591508.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRK

Protein Name

Nik related kinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000434830

InnateDB Gene

IDBG-81057 (NRK)

Protein Structure

UniProt Annotation

Function

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007256	activation of JNKK activity
GO:0007567	parturition
GO:0008285	negative regulation of cell proliferation
GO:0023014	signal transduction by phosphorylation
GO:0050790	regulation of catalytic activity
GO:0060721	regulation of spongiotrophoblast cell proliferation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt