InnateDB Protein
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IDBP-591513.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HS3ST5
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Protein Name
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heparan sulfate (glucosamine) 3-O-sulfotransferase 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000440332
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InnateDB Gene
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IDBG-408918 (HS3ST5)
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Protein Structure
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Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O- sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269PubMed:12138164}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon. {ECO:0000269PubMed:12138164, ECO:0000269PubMed:12740361}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0008146
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sulfotransferase activity
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GO:0008467
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[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
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GO:0050656
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3'-phosphoadenosine 5'-phosphosulfate binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00685
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IZT8
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PhosphoSite |
PhosphoSite-Q8IZT8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
222537
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UniGene |
Hs.691889
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RefSeq |
NP_705840
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HUGO |
HGNC:19419
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OMIM |
609407
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CCDS |
CCDS34517
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HPRD |
13674
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IMGT |
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EMBL |
AF503292
AK091074
AK289907
BC093911
BC093913
CH471051
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GenPept |
AAH93911
AAH93913
AAN37737
BAF82596
EAW48251
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