InnateDB Protein
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IDBP-591749.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BANP
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Protein Name
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BTG3 associated nuclear protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000432508
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InnateDB Gene
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IDBG-46023 (BANP)
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Protein Structure
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Function |
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16166625}.
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Disease Associations |
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Tissue Specificity |
Down-regulated in breast cancer cell lines. {ECO:0000269PubMed:16166625}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018379
BEN domain
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PFAM |
PF10523
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PRINTS |
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PIRSF |
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SMART |
SM01025
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N9N5
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PhosphoSite |
PhosphoSite-Q8N9N5
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TrEMBL |
C9JYB6
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UniProt Splice Variant |
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Entrez Gene |
54971
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UniGene |
Hs.690969
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RefSeq |
NP_001167012
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HUGO |
HGNC:13450
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OMIM |
611564
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CCDS |
CCDS54053
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HPRD |
16538
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IMGT |
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EMBL |
AC127455
AC134312
AK000545
AK094158
AK125232
AK297945
AK315089
AK315535
BC009424
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GenPept |
AAH09424
BAA91244
BAC04296
BAG37554
BAG54171
BAG60261
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