InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHRS4

Summary

InnateDB Protein

IDBP-591780.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHRS4

Protein Name

dehydrogenase/reductase (SDR family) member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000453367

InnateDB Gene

IDBG-3418 (DHRS4)

Protein Structure

UniProt Annotation

Function

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000269PubMed:10333503}. Note=Isoform 1 is peroxisomal, while isoform 4 is not.Isoform 7: Nucleus {ECO:0000269PubMed:22227495}.

Disease Associations

Tissue Specificity

Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000253	3-keto sterol reductase activity
GO:0004090	carbonyl reductase (NADPH) activity
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity

Biological Process

GO:0006066	alcohol metabolic process
GO:0008152	metabolic process
GO:0008202	steroid metabolic process
GO:0042180	cellular ketone metabolic process
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome