InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHST7

Summary

InnateDB Protein

IDBP-59180.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST7

Protein Name

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000276055

InnateDB Gene

IDBG-59178 (CHST7)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. {ECO:0000269PubMed:10781596, ECO:0000269PubMed:10913333, ECO:0000269PubMed:10956661}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin. {ECO:0000269PubMed:10781596, ECO:0000269PubMed:10913333, ECO:0000269PubMed:10956661}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146	sulfotransferase activity
GO:0008459	chondroitin 6-sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005976	polysaccharide metabolic process
GO:0006044	N-acetylglucosamine metabolic process
GO:0006790	sulfur compound metabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0044281	small molecule metabolic process