InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTN3

Summary

InnateDB Protein

IDBP-591807.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTN3

Protein Name

histatin 3

Synonyms

HIS2; HTN2; HTN5;

Species

Homo sapiens

Ensembl Protein

ENSP00000437158

InnateDB Gene

IDBG-22181 (HTN3)

Protein Structure

UniProt Annotation

Function

Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. {ECO:0000269PubMed:11179305, ECO:0000269PubMed:8945538}.

Subcellular Localization

Secreted {ECO:0000269PubMed:14966203}. Note=Secreted by serous acinar and demilune cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0031214	biomineral tissue development
GO:0031640	killing of cells of other organism
GO:0042742	defense response to bacterium
GO:0050832	defense response to fungus