InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPS6KA5

Summary

InnateDB Protein

IDBP-591942.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KA5

Protein Name

ribosomal protein S6 kinase, 90kDa, polypeptide 5

Synonyms

MSK1; MSPK1; RLPK;

Species

Homo sapiens

Ensembl Protein

ENSP00000442803

InnateDB Gene

IDBG-16084 (RPS6KA5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.

Experimentally validated
Total	80 [view]
Protein-Protein	72 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005840	ribosome
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002575 Aminoglycoside phosphotransferase
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR016239 Ribosomal protein S6 kinase II
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF01636
PF06293
PF00433

PRINTS

PR00109

PIRSF

PIRSF000606

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References