InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDIT3

Summary

InnateDB Protein

IDBP-591966.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDIT3

Protein Name

DNA-damage-inducible transcript 3

Synonyms

CEBPZ; CHOP; CHOP-10; CHOP10; GADD153;

Species

Homo sapiens

Ensembl Protein

ENSP00000447803

InnateDB Gene

IDBG-42805 (DDIT3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	80 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0006986	response to unfolded protein
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007050	cell cycle arrest
GO:0016055	Wnt signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032757	positive regulation of interleukin-8 production
GO:0034976	response to endoplasmic reticulum stress
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043620	regulation of DNA-dependent transcription in response to stress
GO:0044267	cellular protein metabolic process
GO:0044324	regulation of transcription involved in anterior/posterior axis specification
GO:0045087	innate immune response (InnateDB)
GO:0045454	cell redox homeostasis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000016	negative regulation of determination of dorsal identity