InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCAT1

Summary

InnateDB Protein

IDBP-592015.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCAT1

Protein Name

branched chain amino-acid transaminase 1, cytosolic

Synonyms

BCATC; BCT1; ECA39; MECA39; PNAS121; PP18;

Species

Homo sapiens

Ensembl Protein

ENSP00000440817

InnateDB Gene

IDBG-23682 (BCAT1)

Protein Structure

UniProt Annotation

Function

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004084	branched-chain-amino-acid transaminase activity
GO:0052654	L-leucine transaminase activity
GO:0052655	L-valine transaminase activity
GO:0052656	L-isoleucine transaminase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0009081	branched-chain amino acid metabolic process
GO:0009082	branched-chain amino acid biosynthetic process
GO:0009083	branched-chain amino acid catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process