Version 5.4
Homo sapiens Protein: CCDC62
Summary
InnateDB Protein IDBP-592080.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCDC62
Protein Name coiled-coil domain containing 62
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000445045
InnateDB Gene IDBG-62878 (CCDC62)
Protein Structure
UniProt Annotation
Function Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. {ECO:0000269PubMed:19126643}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19126643}. Nucleus {ECO:0000269PubMed:19126643}. Note=Mainly nuclear.
Disease Associations
Tissue Specificity Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR (PubMed:19165854). Overexpressed in various cancers. {ECO:0000269PubMed:19126643, ECO:0000269PubMed:19165854, ECO:0000269Ref.1, ECO:0000269Ref.4}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030331 estrogen receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071392 cellular response to estradiol stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P9F0
PhosphoSite PhosphoSite-Q6P9F0
TrEMBL
UniProt Splice Variant
Entrez Gene 84660
UniGene Hs.736480
RefSeq
HUGO HGNC:30723
OMIM 613481
CCDS
HPRD 15575
IMGT
EMBL AK097663 AK124633 AK292466 AY009105 AY254201 BC060796
GenPept AAG49396 AAH60796 AAP13075 BAC85909 BAF85155 BAG53505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca