Version 5.4
Homo sapiens Protein: SLC9A7
Summary
InnateDB Protein IDBP-59215.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC9A7
Protein Name solute carrier family 9 (sodium/hydrogen exchanger), member 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000330320
InnateDB Gene IDBG-59213 (SLC9A7)
Protein Structure
UniProt Annotation
Function Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis. {ECO:0000269PubMed:11279194}.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:15840657}; Multi-pass membrane protein {ECO:0000269PubMed:15840657}. Recycling endosome membrane {ECO:0000269PubMed:15840657}; Multi-pass membrane protein {ECO:0000269PubMed:15840657}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:11279194}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0015386 potassium:hydrogen antiporter activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
GO:0055038 recycling endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR002090 Na+/H+ exchanger, isoform 6 (NHE6)
IPR004709 Na+/H+ exchanger
IPR006153 Cation/H+ exchanger
PFAM PF00999
PRINTS PR01088
PR01084
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96T83
PhosphoSite PhosphoSite-Q96T83
TrEMBL A0A024R176
UniProt Splice Variant
Entrez Gene 84679
UniGene Hs.91389
RefSeq NP_115980
HUGO HGNC:17123
OMIM 300368
CCDS CCDS14269
HPRD 02297
IMGT
EMBL AF298591 AL022165 AL050307 CH471164
GenPept AAK54508 CAI43015 CAI43029 EAW59270 EAW59271 EAW59272

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca