InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF3M

Summary

InnateDB Protein

IDBP-592548.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF3M

Protein Name

eukaryotic translation initiation factor 3, subunit M

Synonyms

B5; hfl-B5; PCID1; TANGO7;

Species

Homo sapiens

Ensembl Protein

ENSP00000436049

InnateDB Gene

IDBG-38246 (EIF3M)

Protein Structure

UniProt Annotation

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000255HAMAP-Rule:MF_03012, ECO:0000269PubMed:15919898, ECO:0000269PubMed:17403899}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03012}.

Disease Associations

Tissue Specificity

Broadly expressed. {ECO:0000269PubMed:15919898}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0031369	translation initiation factor binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0002183	cytoplasmic translational initiation
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation

Cellular Component

GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m