InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKCQ

Summary

InnateDB Protein

IDBP-592589.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCQ

Protein Name

protein kinase C, theta

Synonyms

nPKC-theta; PRKCT;

Species

Homo sapiens

Ensembl Protein

ENSP00000441752

InnateDB Gene

IDBG-51302 (PRKCQ)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006509	membrane protein ectodomain proteolysis
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006954	inflammatory response
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0007603	phototransduction, visible light
GO:0016056	rhodopsin mediated signaling pathway
GO:0016567	protein ubiquitination
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0030168	platelet activation
GO:0032740	positive regulation of interleukin-17 production
GO:0032753	positive regulation of interleukin-4 production
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050852	T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070233	negative regulation of T cell apoptotic process
GO:0090330	regulation of platelet aggregation
GO:2000318	positive regulation of T-helper 17 type immune response
GO:2000570	positive regulation of T-helper 2 cell activation

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00130
PF00433

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00133
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt