Version 5.4
Homo sapiens Protein: PTGR2
Summary
InnateDB Protein IDBP-592691.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGR2
Protein Name prostaglandin reductase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000450975
InnateDB Gene IDBG-11675 (PTGR2)
Protein Structure
UniProt Annotation
Function Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:15004468}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0036132 13-prostaglandin reductase activity
GO:0047522 15-oxoprostaglandin 13-oxidase activity
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
PFAM PF00107
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N8N7
PhosphoSite PhosphoSite-Q8N8N7
TrEMBL V9HW32
UniProt Splice Variant
Entrez Gene 145482
UniGene Hs.632344
RefSeq NP_001139627
HUGO HGNC:20149
OMIM 608642
CCDS CCDS9820
HPRD 09782
IMGT
EMBL AC005520 AK096410 AY346133 AY424308 BC059364 BX641118 CH471061 FJ224334
GenPept AAH59364 AAR05101 AAR82927 ACI46026 BAC04781 CAE46055 EAW81132 EAW81135

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca