InnateDB Protein
|
IDBP-592719.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MYRIP
|
Protein Name
|
myosin VIIA and Rab interacting protein
|
Synonyms
|
SLAC2-C; SLAC2C;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000438297
|
InnateDB Gene
|
IDBG-27001 (MYRIP)
|
Protein Structure
|
|
Function |
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR006788
Rab effector MyRIP/Melanophilin
|
PFAM |
PF04698
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8NFW9
|
PhosphoSite |
PhosphoSite-Q8NFW9
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
25924
|
UniGene |
Hs.651362
|
RefSeq |
NP_001271355
|
HUGO |
HGNC:19156
|
OMIM |
611790
|
CCDS |
CCDS68392
|
HPRD |
14796
|
IMGT |
|
EMBL |
AB083783
AC099331
AC099557
AC104188
AC110718
AC130439
AF396687
AK125334
AK126013
AK294714
AK316068
AL050090
BC092512
BC109311
BC109312
CH471055
|
GenPept |
AAH92512
AAI09312
AAI09313
AAM43954
BAC15555
BAG54185
BAG54276
BAH11857
BAH14439
CAB43262
EAW64595
|
|
|