Version 5.4
Homo sapiens Protein: VAMP5
Summary
InnateDB Protein IDBP-59276.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAMP5
Protein Name vesicle-associated membrane protein 5 (myobrevin)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305647
InnateDB Gene IDBG-59274 (VAMP5)
Protein Structure
UniProt Annotation
Function May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Endomembrane system {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0016192 vesicle-mediated transport
GO:0030154 cell differentiation
GO:0043001 Golgi to plasma membrane protein transport
Cellular Component
GO:0005770 late endosome
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0014704 intercalated disc
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031301 integral component of organelle membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/Vesicle-associated membrane protein
PFAM PF00957
PRINTS PR00219
PIRSF PIRSF005409
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95183
PhosphoSite PhosphoSite-O95183
TrEMBL Q6FG93
UniProt Splice Variant
Entrez Gene 10791
UniGene
RefSeq NP_006625
HUGO HGNC:12646
OMIM 607029
CCDS CCDS1980
HPRD 09513
IMGT
EMBL AC016753 AF054825 AF077197 AF151025 AK292660 BC017891 CH471053 CR542215
GenPept AAC97473 AAD26992 AAF36111 AAH17891 AAY24342 BAF85349 CAG47011 EAW99508

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca