InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP1B3

Summary

InnateDB Protein

IDBP-59282.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP1B3

Protein Name

ATPase, Na+/K+ transporting, beta 3 polypeptide

Synonyms

ATPB-3; CD298;

Species

Homo sapiens

Ensembl Protein

ENSP00000286371

InnateDB Gene

IDBG-59280 (ATP1B3)

Protein Structure

UniProt Annotation

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0007596	blood coagulation
GO:0030001	metal ion transport
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050900	leukocyte migration
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome