InnateDB Protein
|
IDBP-592827.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
NOL8
|
Protein Name
|
nucleolar protein 8
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000440709
|
InnateDB Gene
|
IDBG-76039 (NOL8)
|
Protein Structure
|
|
Function |
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269PubMed:14660641, ECO:0000269PubMed:15132771, ECO:0000269PubMed:16963496}.
|
Subcellular Localization |
Nucleus, nucleolus {ECO:0000269PubMed:15132771, ECO:0000269PubMed:16963496}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.
|
Disease Associations |
|
Tissue Specificity |
Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle. {ECO:0000269PubMed:15132771}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
8
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q76FK4
|
PhosphoSite |
PhosphoSite-Q76FK4
|
TrEMBL |
F5H7D5
|
UniProt Splice Variant |
|
Entrez Gene |
55035
|
UniGene |
Hs.442199
|
RefSeq |
XP_006717234
|
HUGO |
HGNC:23387
|
OMIM |
611534
|
CCDS |
CCDS59135
|
HPRD |
11397
|
IMGT |
|
EMBL |
AB105104
AB109030
AK000743
AK001049
AK022755
AK024245
AK024786
AL136097
BC013788
|
GenPept |
AAH13788
BAA91356
BAA91479
BAB14229
BAB14857
BAB15003
BAC99315
BAD12268
|
|
|