InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNJ2

Summary

InnateDB Protein

IDBP-592949.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ2

Protein Name

potassium inwardly-rectifying channel, subfamily J, member 2

Synonyms

ATFB9; HHBIRK1; HHIRK1; IRK1; KIR2.1; LQT7; SQT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000441848

InnateDB Gene

IDBG-66556 (KCNJ2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

Biological Process

GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0010107	potassium ion import
GO:0014861	regulation of skeletal muscle contraction via regulation of action potential
GO:0030007	cellular potassium ion homeostasis
GO:0051289	protein homotetramerization
GO:0055119	relaxation of cardiac muscle
GO:0060075	regulation of resting membrane potential
GO:0060306	regulation of membrane repolarization
GO:0071805	potassium ion transmembrane transport
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086011	membrane repolarization during action potential
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:0090076	relaxation of skeletal muscle

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016021	integral component of membrane
GO:0031224	intrinsic component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003271 Potassium channel, inwardly rectifying, Kir2.1
IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal
IPR014756 Immunoglobulin E-set
IPR016449 Potassium channel, inwardly rectifying, Kir

PFAM

PF08466
PF01007

PRINTS

PR01324
PR01320

PIRSF

PIRSF005465

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt