InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATF7

Summary

InnateDB Protein

IDBP-592975.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATF7

Protein Name

activating transcription factor 7

Synonyms

ATFA;

Species

Homo sapiens

Ensembl Protein

ENSP00000449938

InnateDB Gene

IDBG-37050 (ATF7)

Protein Structure

UniProt Annotation

Function

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.Isoform 4/ATF-A0 acts as a dominant repressor of the E- selectin/NF-ELAM1/delta-A promoter.Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:17264123}. Nucleus, nucleoplasm {ECO:0000269PubMed:17264123}. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.Isoform 5: Cytoplasm {ECO:0000269PubMed:21858082}.

Disease Associations

Tissue Specificity

Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta. {ECO:0000269PubMed:8288576}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016032	viral process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0034399	nuclear periphery

Protein Structure and Domains

PDB ID

InterPro

IPR004827 Basic-leucine zipper domain
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR016378 Transcription factor, cyclic AMP-dependent

PFAM

PF00170
PF07716
PF00096

PRINTS

PIRSF

PIRSF003153

SMART

SM00338
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt