Homo sapiens Protein: NDUFS3
Summary
InnateDB Protein IDBP-593001.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol NDUFS3
Protein Name NADH:ubiquinone oxidoreductase core subunit S3
Synonyms CI-30;
Species Homo sapiens
Ensembl Protein ENSP00000263774
InnateDB Gene IDBG-127610 (NDUFS3)
Protein Structure
UniProt Annotation
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 204 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 204 [view]
Protein-Protein 201 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003954 NADH dehydrogenase activity
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0021762 substantia nigra development
GO:0030308 negative regulation of cell growth
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0045333 cellular respiration
GO:0055114 oxidation-reduction process
GO:0072593 reactive oxygen species metabolic process
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0016604 nuclear body
GO:0031966 mitochondrial membrane
GO:0043209 myelin sheath
GO:0070469 respiratory chain
Protein Structure and Domains
PDB ID
InterPro IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit
IPR010218 NADH dehydrogenase, subunit C
IPR020396 NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
IPR037232 NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily
PFAM PF00329
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75489
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 4722
UniGene
RefSeq NP_004542
HUGO HGNC:7710
OMIM 603846
CCDS CCDS7941
HPRD
IMGT
EMBL AC090559 AC104942 AF067139 AF100743 AF200954 AK294167 AK313802 BC000617 CH471064
GenPept AAC27451 AAD40386 AAG17541 AAH00617 BAG36538 BAG57489 EAW67895