InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF24

Summary

InnateDB Protein

IDBP-59310.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF24

Protein Name

kinesin family member 24

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368464

InnateDB Gene

IDBG-59300 (KIF24)

Protein Structure

UniProt Annotation

Function

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. {ECO:0000269PubMed:21620453}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:21620453}. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007019	microtubule depolymerization
GO:0008152	metabolic process
GO:0042384	cilium assembly

Cellular Component

GO:0005814	centriole
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR001752 Kinesin, motor domain
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00225
PF00536

PRINTS

PR00380

PIRSF

SMART

SM00454
SM00129

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt