InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GALNT4

Summary

InnateDB Protein

IDBP-593568.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALNT4

Protein Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)

Synonyms

GALNAC-T4; GALNACT4;

Species

Homo sapiens

Ensembl Protein

ENSP00000436604

InnateDB Gene

IDBG-545254 (GALNT4)

Protein Structure

UniProt Annotation

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305PubMed:9804815}; Single-pass type II membrane protein {ECO:0000305PubMed:9804815}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in mucous cells. {ECO:0000269PubMed:9804815}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0016266	O-glycan processing
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome