InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PARN

Summary

InnateDB Protein

IDBP-593583.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARN

Protein Name

poly(A)-specific ribonuclease

Synonyms

DAN;

Species

Homo sapiens

Ensembl Protein

ENSP00000444381

InnateDB Gene

IDBG-15347 (PARN)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004535	poly(A)-specific ribonuclease activity
GO:0046872	metal ion binding

Biological Process

GO:0006402	mRNA catabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR006941 Ribonuclease CAF1
IPR012337 Ribonuclease H-like domain
IPR014789 Poly(A)-specific ribonuclease, RNA-binding

PFAM

PF04857
PF08675

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B4DSB0

UniProt Splice Variant

Entrez Gene

5073

UniGene

Hs.707451

RefSeq

HUGO

HGNC:8609

OMIM

604212

CCDS

HPRD

07250

IMGT

EMBL

AC009167 AC092291 AK023866 AK299653

GenPept

BAG51231 BAG61572