InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF111

Summary

InnateDB Protein

IDBP-593667.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF111

Protein Name

ring finger protein 111

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000453015

InnateDB Gene

IDBG-14393 (RNF111)

Protein Structure

UniProt Annotation

Function

Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme. {ECO:0000269PubMed:14657019, ECO:0000269PubMed:16601693, ECO:0000269PubMed:17591695, ECO:0000269PubMed:22411132}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16601693}. Cytoplasm {ECO:0000269PubMed:16601693}. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol.

Disease Associations

Tissue Specificity

Broadly expressed. {ECO:0000269PubMed:14657019}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	56 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0032184	SUMO polymer binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter