InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TESC

Summary

InnateDB Protein

IDBP-59391.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TESC

Protein Name

tescalcin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000334785

InnateDB Gene

IDBG-59389 (TESC)

Protein Structure

UniProt Annotation

Function

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269PubMed:17717601, ECO:0000269PubMed:18321853, ECO:0000269PubMed:20060826}.

Subcellular Localization

Nucleus. Cytoplasm. Membrane {ECO:0000250}. Cell membrane. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Colocalizes with SLC9A1 at the plasma membrane.

Disease Associations

Tissue Specificity

Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta. {ECO:0000269PubMed:11696366, ECO:0000269PubMed:20060826}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004860	protein kinase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019212	phosphatase inhibitor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010628	positive regulation of gene expression
GO:0030219	megakaryocyte differentiation
GO:0030854	positive regulation of granulocyte differentiation
GO:0032417	positive regulation of sodium:proton antiporter activity
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0043086	negative regulation of catalytic activity
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050821	protein stabilization
GO:0051604	protein maturation
GO:0071300	cellular response to retinoic acid
GO:0072661	protein targeting to plasma membrane