InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SSTR4

Summary

InnateDB Protein

IDBP-59396.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSTR4

Protein Name

somatostatin receptor 4

Synonyms

SS-4-R; SS4-R; SS4R;

Species

Homo sapiens

Ensembl Protein

ENSP00000255008

InnateDB Gene

IDBG-59392 (SSTR4)

Protein Structure

UniProt Annotation

Function

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0008285	negative regulation of cell proliferation
GO:0016477	cell migration
GO:0019369	arachidonic acid metabolic process
GO:0030815	negative regulation of cAMP metabolic process
GO:0030900	forebrain development
GO:0043410	positive regulation of MAPK cascade
GO:0071385	cellular response to glucocorticoid stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000586 Somatostatin receptor family
IPR000611 Neuropeptide Y receptor family
IPR001116 Somatostatin receptor 1
IPR001418 Opioid receptor
IPR001512 Somatostatin receptor 4
IPR009150 Neuropeptide B/W receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019427 7TM GPCR, serpentine receptor class w (Srw)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10324
PF10328

PRINTS