InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUDT2

Summary

InnateDB Protein

IDBP-59423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT2

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 2

Synonyms

APAH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000368455

InnateDB Gene

IDBG-59421 (NUDT2)

Protein Structure

UniProt Annotation

Function

Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	3 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0005525	GTP binding
GO:0008803	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
GO:0016787	hydrolase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006915	apoptotic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000086 NUDIX hydrolase domain
IPR003565 Bis(5\'-nucleosyl)-tetraphosphatase
IPR015797 NUDIX hydrolase domain-like

PFAM

PF00293

PRINTS

PR01405

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50583

PhosphoSite

PhosphoSite-P50583

TrEMBL

UniProt Splice Variant

Entrez Gene

318

UniGene

Hs.731743

RefSeq

NP_001152

HUGO

HGNC:8049

OMIM

602852

CCDS

CCDS6552

HPRD

04168

IMGT

EMBL

AL356494 BC004926 CH471071 U30313

GenPept

AAC50277 AAH04926 CAI15964 EAW58461 EAW58462 EAW58463