InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPB41L2

Summary

InnateDB Protein

IDBP-594391.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPB41L2

Protein Name

erythrocyte membrane protein band 4.1-like 2

Synonyms

4.1-G; 4.1G;

Species

Homo sapiens

Ensembl Protein

ENSP00000432803

InnateDB Gene

IDBG-96444 (EPB41L2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000269PubMed:22361696}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005198	structural molecule activity

Biological Process

GO:0030866

cortical actin cytoskeleton organization

Cellular Component

GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0008091	spectrin
GO:0008180	COP9 signalosome
GO:0019898	extrinsic component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR008379 Band 4.1, C-terminal
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR021187 Band 4.1 protein
IPR029071 Ubiquitin-related domain

PFAM

PF05902
PF08736
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002304

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References