InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K9

Summary

InnateDB Protein

IDBP-594773.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K9

Protein Name

mitogen-activated protein kinase kinase kinase 9

Synonyms

MEKK9; MLK1; PRKE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000451263

InnateDB Gene

IDBG-10857 (MAP3K9)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269PubMed:11416147, ECO:0000269PubMed:15610029}.

Subcellular Localization

Disease Associations

Note=May play a role in esophageal cancer susceptibility and/or development.

Tissue Specificity

Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. {ECO:0000269PubMed:8477742}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004706	JUN kinase kinase kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0008219	cell death
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR016137 Regulator of G protein signalling superfamily
IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, 9/10/11
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00018
PF14604
PF07653

PRINTS

PR00109
PR00452

PIRSF

PIRSF000556

SMART

SM00326
SM00220
SM00315
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References