InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOS1

Summary

InnateDB Protein

IDBP-59493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOS1

Protein Name

nitric oxide synthase 1 (neuronal)

Synonyms

bNOS; IHPS1; N-NOS; NC-NOS; nNOS; NOS;

Species

Homo sapiens

Ensembl Protein

ENSP00000320758

InnateDB Gene

IDBG-59491 (NOS1)

Protein Structure

UniProt Annotation

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

Subcellular Localization

Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine {ECO:0000250}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0004517	nitric-oxide synthase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0017080	sodium channel regulator activity
GO:0020037	heme binding
GO:0034617	tetrahydrobiopterin binding
GO:0034618	arginine binding
GO:0044325	ion channel binding
GO:0046870	cadmium ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding
GO:0097110	scaffold protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0006527	arginine catabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0007263	nitric oxide mediated signal transduction
GO:0007520	myoblast fusion
GO:0007596	blood coagulation
GO:0009408	response to heat
GO:0010523	negative regulation of calcium ion transport into cytosol
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0031284	positive regulation of guanylate cyclase activity
GO:0033555	multicellular organismal response to stress
GO:0042136	neurotransmitter biosynthetic process
GO:0045776	negative regulation of blood pressure
GO:0045909	positive regulation of vasodilation
GO:0051701	interaction with host
GO:0055114	oxidation-reduction process
GO:0055117	regulation of cardiac muscle contraction
GO:0090382	phagosome maturation
GO:1902307	positive regulation of sodium ion transmembrane transport

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016529	sarcoplasmic reticulum
GO:0042383	sarcolemma
GO:0043197	dendritic spine
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001094 Flavodoxin
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001478 PDZ domain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097 FAD-binding, type 1
IPR004030 Nitric oxide synthase, N-terminal
IPR008254 Flavodoxin/nitric oxide synthase
IPR012144 Nitric-oxide synthase, eukaryote
IPR017938 Riboflavin synthase-like beta-barrel
IPR029039 Flavoprotein-like

PFAM

PF00175
PF00595
PF13180
PF00667
PF02898
PF00258

PRINTS

PR00369
PR00371

PIRSF

PIRSF000333

SMART

SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References