Version 5.4
Homo sapiens Protein: RGN
Summary
InnateDB Protein IDBP-59500.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGN
Protein Name regucalcin (senescence marker protein-30)
Synonyms GNL; HEL-S-41; RC; SMP30;
Species Homo sapiens
Ensembl Protein ENSP00000253303
InnateDB Gene IDBG-59498 (RGN)
Protein Structure
UniProt Annotation
Function Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004341 gluconolactonase activity
GO:0005509 calcium ion binding
GO:0008270 zinc ion binding
GO:0030234 enzyme regulator activity
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0032781 positive regulation of ATPase activity
GO:0050848 regulation of calcium-mediated signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR005511 Senescence marker protein-30 (SMP-30)
IPR008367 Regucalcin
IPR013658 SMP-30/Gluconolactonase/LRE-like region
PFAM PF08450
PRINTS PR01790
PR01791
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15493
PhosphoSite PhosphoSite-Q15493
TrEMBL V9HWF8
UniProt Splice Variant
Entrez Gene 9104
UniGene Hs.77854
RefSeq NP_004674
HUGO HGNC:9989
OMIM 300212
CCDS CCDS14272
HPRD 02196
IMGT
EMBL AB028125 AB032064 AK223360 AK290136 AL513366 BC050371 BC073173 D31815 EU794655
GenPept AAH50371 AAH73173 ACJ13709 BAA06602 BAA78693 BAA84082 BAD97080 BAF82825 CAI41697

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca