InnateDB Protein
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IDBP-595095.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CREBZF
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Protein Name
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CREB/ATF bZIP transcription factor
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000433459
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InnateDB Gene
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IDBG-66455 (CREBZF)
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Protein Structure
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Function |
Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1- dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269PubMed:10871379, ECO:0000269PubMed:15705566}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15705566}. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.
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Disease Associations |
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Tissue Specificity |
In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver. {ECO:0000269PubMed:10871379}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0009615
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response to virus
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GO:0045814
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negative regulation of gene expression, epigenetic
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0051090
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regulation of sequence-specific DNA binding transcription factor activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR004827
Basic-leucine zipper domain
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PFAM |
PF00170
PF07716
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PRINTS |
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PIRSF |
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SMART |
SM00338
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NS37
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PhosphoSite |
PhosphoSite-Q9NS37
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
58487
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UniGene |
Hs.703769
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RefSeq |
NP_001034707
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HUGO |
HGNC:24905
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OMIM |
606444
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CCDS |
CCDS41697
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HPRD |
07340
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IMGT |
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EMBL |
AF039942
AK313471
AP000642
BC060807
BC093796
BC093798
DQ128105
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GenPept |
AAD28325
AAH60807
AAH93796
AAH93798
AAZ42189
BAG36256
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