InnateDB Protein
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IDBP-595341.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HOMER3
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Protein Name
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homer homolog 3 (Drosophila)
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Synonyms
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HOMER-3; VESL3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000439937
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InnateDB Gene
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IDBG-39136 (HOMER3)
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Protein Structure
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Function |
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
32
[view]
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Protein-Protein |
32
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000697
WH1/EVH1
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PFAM |
PF00568
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PRINTS |
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PIRSF |
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SMART |
SM00461
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NSC5
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PhosphoSite |
PhosphoSite-Q9NSC5
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TrEMBL |
M0R2U7
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UniProt Splice Variant |
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Entrez Gene |
9454
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UniGene |
Hs.720208
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RefSeq |
XP_006723006
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HUGO |
HGNC:17514
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OMIM |
604800
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CCDS |
CCDS12391
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HPRD |
07270
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IMGT |
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EMBL |
AC002985
AF093265
BC012113
Y17573
Y18894
Y18895
Y18896
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GenPept |
AAB81545
AAC71029
AAH12113
CAB75536
CAB75543
CAB75544
CAB75545
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