Version 5.4
Homo sapiens Protein: GSN
Summary
InnateDB Protein IDBP-595468.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSN
Protein Name gelsolin
Synonyms ADF; AGEL;
Species Homo sapiens
Ensembl Protein ENSP00000445823
InnateDB Gene IDBG-83407 (GSN)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0030041 actin filament polymerization
GO:0051014 actin filament severing
GO:0051016 barbed-end actin filament capping
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR007122 Villin/Gelsolin
IPR007123 Gelsolin-like domain
PFAM PF00626
PRINTS PR00597
PIRSF
SMART SM00262
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P06396
PhosphoSite PhosphoSite-P06396
TrEMBL V9H1C1
UniProt Splice Variant
Entrez Gene 2934
UniGene
RefSeq NP_001244959
HUGO HGNC:4620
OMIM 137350
CCDS CCDS65118
HPRD 00674
IMGT
EMBL AK096280 AK125819 AK295572 AK299453 AK315494 AL137068 AL513122 BC017491 BC026033 CH471090 X04412 X07066
GenPept AAH17491 AAH26033 BAG37878 BAG53247 BAG54252 BAH12109 BAH13037 CAA28000 CAA30102 CAI14413 CAM20459 EAW87489 EAW87490 EAW87491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca