InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERCC5

Summary

InnateDB Protein

IDBP-595513.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERCC5

Protein Name

excision repair cross-complementing rodent repair deficiency, complementation group 5

Synonyms

COFS3; ERCC5-201; ERCM2; UVDR; XPG; XPGC;

Species

Homo sapiens

Ensembl Protein

ENSP00000442117

InnateDB Gene

IDBG-49163 (ERCC5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000405	bubble DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0004520	endodeoxyribonuclease activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000718	nucleotide-excision repair, DNA damage removal
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0009411	response to UV
GO:0009650	UV protection
GO:0010225	response to UV-C
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005662	DNA replication factor A complex
GO:0005675	holo TFIIH complex
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0045111	intermediate filament cytoskeleton