Version 5.4
Homo sapiens Protein: FGF7
Summary
InnateDB Protein IDBP-595538.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF7
Protein Name fibroblast growth factor 7
Synonyms HBGF-7; KGF;
Species Homo sapiens
Ensembl Protein ENSP00000454205
InnateDB Gene IDBG-11473 (FGF7)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042056 chemoattractant activity
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0009611 response to wounding
GO:0010463 mesenchymal cell proliferation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0031532 actin cytoskeleton reorganization
GO:0034394 protein localization to cell surface
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0051549 positive regulation of keratinocyte migration
GO:0051781 positive regulation of cell division
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0061033 secretion by lung epithelial cell involved in lung growth
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR008996 Cytokine, IL-1-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P21781
PhosphoSite PhosphoSite-P21781
TrEMBL
UniProt Splice Variant
Entrez Gene 2252
UniGene Hs.735177
RefSeq
HUGO HGNC:3685
OMIM 148180
CCDS
HPRD 01022
IMGT
EMBL AC022306 AC025919 AK313160 BC010956 CH471082 CR542002 M60828 S81661
GenPept AAA63210 AAB21431 AAH10956 BAG35978 CAG46799 EAW77375 EAW77376

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca