InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BDKRB2

Summary

InnateDB Protein

IDBP-595700.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BDKRB2

Protein Name

bradykinin receptor B2

Synonyms

B2R; BK-2; BK2; BKR2; BRB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000450482

InnateDB Gene

IDBG-18990 (BDKRB2)

Protein Structure

UniProt Annotation

Function

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. Widespread in normal smooth muscle tissue and neurons. {ECO:0000269PubMed:7835885}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004947	bradykinin receptor activity
GO:0005515	protein binding
GO:0031702	type 1 angiotensin receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006939	smooth muscle contraction
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008015	blood circulation
GO:0008152	metabolic process
GO:0009651	response to salt stress
GO:0019229	regulation of vasoconstriction
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042310	vasoconstriction
GO:0042311	vasodilation
GO:0043114	regulation of vascular permeability
GO:0045087	innate immune response (InnateDB)
GO:0050482	arachidonic acid secretion
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1902239	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000496 Bradykinin receptor family
IPR001504 Bradykinin receptor B2
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00241
PR00237
PR00425
PR00994

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30411