InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCAT2

Summary

InnateDB Protein

IDBP-595844.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCAT2

Protein Name

branched chain amino-acid transaminase 2, mitochondrial

Synonyms

BCAM; BCATM; BCT2; PP18;

Species

Homo sapiens

Ensembl Protein

ENSP00000440973

InnateDB Gene

IDBG-61179 (BCAT2)

Protein Structure

UniProt Annotation

Function

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.

Subcellular Localization

Isoform A: Mitochondrion.Isoform B: Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	7 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004084	branched-chain-amino-acid transaminase activity
GO:0052654	L-leucine transaminase activity
GO:0052655	L-valine transaminase activity
GO:0052656	L-isoleucine transaminase activity

Biological Process

GO:0008152	metabolic process
GO:0009081	branched-chain amino acid metabolic process
GO:0009082	branched-chain amino acid biosynthetic process
GO:0009083	branched-chain amino acid catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process