Version 5.4
Homo sapiens Protein: LRP10
Summary
InnateDB Protein IDBP-595903.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRP10
Protein Name low density lipoprotein receptor-related protein 10
Synonyms LRP9; MST087;
Species Homo sapiens
Ensembl Protein ENSP00000447559
InnateDB Gene IDBG-2861 (LRP10)
Protein Structure
UniProt Annotation
Function Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart. {ECO:0000269PubMed:11123907}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
Cellular Component
GO:0005905 coated pit
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000859 CUB domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
PFAM PF00431
PF00057
PRINTS PR00261
PIRSF
SMART SM00042
SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z4F1
PhosphoSite PhosphoSite-Q7Z4F1
TrEMBL
UniProt Splice Variant
Entrez Gene 26020
UniGene Hs.606547
RefSeq
HUGO HGNC:14553
OMIM 609921
CCDS
HPRD 14311
IMGT
EMBL AF131760 AF172816 AF177336 AK291030 AL080164 AL834518 AY358399 BC064901 BC113714 BC113716 BX161500 CH471078
GenPept AAD20037 AAG17980 AAH64901 AAI13715 AAI13717 AAQ13610 AAQ88765 BAF83719 CAB45753 CAD39174 CAD61944 EAW66232 EAW66235

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca