Version 5.4
Homo sapiens Protein: C9orf24
Summary
InnateDB Protein IDBP-59601.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C9orf24
Protein Name chromosome 9 open reading frame 24
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000297623
InnateDB Gene IDBG-59591 (C9orf24)
Protein Structure
UniProt Annotation
Function May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells. {ECO:0000250, ECO:0000269PubMed:15242845}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000269PubMed:15242845}. Cytoplasm {ECO:0000269PubMed:15242845}. Note=Localizes to the manchette in elongating spermatids (By similarity). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in epithelial cells of nasal polyps and in intact epithelium of bronchial biopsies from subjects with and without asthma. Strong expression in columnar cells with little or no expression in basal epithelial cells along the basement membrane. Strongly expressed in ciliated epithelial cells with lower levels in goblet cells (at protein level). {ECO:0000269PubMed:15242845}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0043014 alpha-tubulin binding
Biological Process
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0043623 cellular protein complex assembly
Cellular Component
GO:0002177 manchette
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NCR6
PhosphoSite PhosphoSite-Q8NCR6
TrEMBL
UniProt Splice Variant
Entrez Gene 84688
UniGene Hs.50334
RefSeq NP_115985
HUGO HGNC:19919
OMIM
CCDS CCDS6554
HPRD 12949
IMGT
EMBL AF367474 AK058087 AK094751 AL356494 BC022084 BC029484
GenPept AAH22084 AAH29484 AAK53410 BAB71657 BAC04412 CAI15976 CAI15977 CAI15978 CAI15979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca