InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSF1R

Summary

InnateDB Protein

IDBP-596095.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF1R

Protein Name

colony stimulating factor 1 receptor

Synonyms

C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000445282

InnateDB Gene

IDBG-53268 (CSF1R)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	35 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005011	macrophage colony-stimulating factor receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019955	cytokine binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030097	hemopoiesis
GO:0030224	monocyte differentiation
GO:0030225	macrophage differentiation
GO:0030316	osteoclast differentiation
GO:0030335	positive regulation of cell migration
GO:0031529	ruffle organization
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0038145	macrophage colony-stimulating factor signaling pathway
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087	innate immune response
GO:0045124	regulation of bone resorption
GO:0045217	cell-cell junction maintenance
GO:0046488	phosphatidylinositol metabolic process
GO:0046777	protein autophosphorylation
GO:0048015	phosphatidylinositol-mediated signaling
GO:0060603	mammary gland duct morphogenesis
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071345	cellular response to cytokine stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090197	positive regulation of chemokine secretion
GO:2000147	positive regulation of cell motility
GO:2000249	regulation of actin cytoskeleton reorganization