InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHBDL2

Summary

InnateDB Protein

IDBP-596166.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHBDL2

Protein Name

rhomboid, veinlet-like 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000441097

InnateDB Gene

IDBG-96584 (RHBDL2)

Protein Structure

UniProt Annotation

Function

Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3. {ECO:0000269PubMed:11672525, ECO:0000269PubMed:15047175}.

Subcellular Localization

Rhomboid-related protein 2, C-terminal fragment: Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NX52

PhosphoSite

PhosphoSite-Q9NX52

TrEMBL

UniProt Splice Variant

Entrez Gene

54933

UniGene

Hs.633604

RefSeq

HUGO

HGNC:16083

OMIM

608962

CCDS

HPRD

07151

IMGT

EMBL

AK000442 AL139260 AY126343 BC013103 BC137108 BC137110

GenPept

AAH13103 AAI37109 AAI37111 AAM95697 BAA91168 CAI23052