Version 5.4
Homo sapiens Protein: BAHD1
Summary
InnateDB Protein IDBP-596185.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAHD1
Protein Name bromo adjacent homology domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000454101
InnateDB Gene IDBG-6364 (BAHD1)
Protein Structure
UniProt Annotation
Function Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269PubMed:19666599, ECO:0000269PubMed:21252314}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19666599}. Chromosome {ECO:0000269PubMed:19666599}. Note=Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3).
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0031507 heterochromatin assembly
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005677 chromatin silencing complex
GO:0005694 chromosome
Protein Structure and Domains
PDB ID
InterPro IPR001025 Bromo adjacent homology (BAH) domain
PFAM PF01426
PRINTS
PIRSF
SMART SM00439
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TBE0
PhosphoSite PhosphoSite-Q8TBE0
TrEMBL
UniProt Splice Variant
Entrez Gene 22893
UniGene Hs.22109
RefSeq
HUGO HGNC:29153
OMIM 613880
CCDS
HPRD 12518
IMGT
EMBL AB023162 AC013356 AL833923 BC022782
GenPept AAH22782 BAA76789 CAD38779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca