Version 5.4
Homo sapiens Protein: C11orf30
Summary
InnateDB Protein IDBP-596197.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C11orf30
Protein Name chromosome 11 open reading frame 30
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000432327
InnateDB Gene IDBG-65156 (C11orf30)
Protein Structure
UniProt Annotation
Function Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. {ECO:0000269PubMed:14651845, ECO:0000269PubMed:19131338}.
Subcellular Localization Nucleus {ECO:0000269PubMed:14651845}. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR005491 EMSY N-terminal
PFAM PF03735
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z589
PhosphoSite PhosphoSite-Q7Z589
TrEMBL
UniProt Splice Variant
Entrez Gene 56946
UniGene Hs.352588
RefSeq
HUGO HGNC:18071
OMIM 608574
CCDS CCDS8244
HPRD 10544
IMGT
EMBL AF226047 AJ430203 AK023651 AP002360 AP003165 AY070433 BC029375 BC033404 BC117265 BC143370 BC143374 BC143376 CH471076
GenPept AAF86947 AAH29375 AAH33404 AAI17266 AAI43371 AAI43375 AAI43377 AAL65260 BAB14627 CAD22881 EAW74998

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca