InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGPAT5

Summary

InnateDB Protein

IDBP-5963.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGPAT5

Protein Name

1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000285518

InnateDB Gene

IDBG-5961 (AGPAT5)

Protein Structure

UniProt Annotation

Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable. {ECO:0000269PubMed:21173190}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:21173190}; Multi-pass membrane protein {ECO:0000269PubMed:21173190}. Nucleus envelope {ECO:0000269PubMed:21173190}. Mitochondrion {ECO:0000269PubMed:21173190}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:16620771, ECO:0000269PubMed:21173190}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006639	acylglycerol metabolic process
GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process

Cellular Component

GO:0005635	nuclear envelope
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane