InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GZF1

Summary

InnateDB Protein

IDBP-59638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GZF1

Protein Name

GDNF-inducible zinc finger protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000338290

InnateDB Gene

IDBG-59636 (GZF1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269PubMed:14522971, ECO:0000269PubMed:16049025}.

Subcellular Localization

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Nuclear localization depends upon NCL.

Disease Associations

Tissue Specificity

Expressed in adult brain, heart, skeletal muscle, kidney and liver. Also detected in fetal brain and kidney, and at lower levels in fetal lung and liver. {ECO:0000269PubMed:14522971}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001206	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated